The following serious adverse reactions are described elsewhere in the labeling: Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Hypotension does occur when the drug is administered rapidly by the intravenous route. Phenytoin may cause bone weakness, because it affects the way your body deals with vitamin D which is important for strong bones.

As with all seizure medications, phenytoin should not be stopped suddenly see Dilantin Withdrawal. Strange behavior or thinking may be a sign of too much phenytoin in your blood. Let your healthcare provider know if you notice any unusual behavior or thinking. Because phenytoin can cause gum problems, good dental care is very important while you are taking phenytoin.

In the other woman taking mg 3 times daily, milk levels averaged 0. In one, milk levels ranged from 1. The highest levels were reported on day 6. In the other, levels ranged from 1 to 2. Breastmilk levels varied during the day, with a level of 1.

The trough level of 1. From 1 pm until 8 am the next morning, milk levels fluctuated between 0. Phenytoin milk levels averaged 0. Lymph nodes may swell, sometimes painfully.

Phenytoin causes serum glucose sugar to rise. Thus, blood sugar should be monitored closely when phenytoin is administered to patients with diabetes. Phenytoin can potentially injure the liver although this is an uncommon occurrence. Most of the levels were in the range of 0. Six breastfed infants whose mothers were taking phenytoin to mg daily had serum phenytoin levels measured between 1 and 3 months of age.

A mother was takingphenobarbital mg daily and phenytoin mg daily during pregnancy and postpartum. Her infant was drowsy at birth, refused to suck and was given partial formula feeding.

At 5 days of age, her infant was admitted to the hospital pale and collapsed with bruising, bleeding, and a decreased hemoglobin, thought to be due to methemoglobinemia. Breastfeeding was discontinued and the infant was given a transfusion which rapidly improved her condition.

On day 10, the mother resumed breastfeeding the infant. Within 24 hours the infant was extremely sedated and refused to suck and was fed breastmilk with a spoon. The sedation persisted for 2 days until breastmilk was discontinued permanently because of a return of methemoglobinemia. The extreme sedation was probably due tophenobarbitalin the milk and the methemoglobinemia was probably caused by the phenytoin. The highest levels were reported on day 6. In the other, levels ranged from 1 to 2.

Breastmilk levels varied during the day, with a level of 1. The trough level of 1. From 1 pm until 8 am the next morning, milk levels fluctuated between 0. Phenytoin milk levels averaged 0. One who was taking mg daily had a milk level of 2. In one taking mg daily, a breastmilk levels of 0. In 4 others taking mg daily, milk levels on several occasions mostly during the first week postpartum ranged from 0.

Phenytoin Breastfeeding LactMed Database

Thus, blood sugar should be monitored closely when phenytoin is administered to patients with diabetes. Drowsiness due to clemastine transmitted in breast and. Dietary lipids and postnatal development. A mother was takingphenobarbital mg daily and phenytoin mg daily during pregnancy and postpartum. Probably due to phenytoin excreted in human milk. Vitamin D deficiencydilantin well as low calcium and phosphate in the breastfeed cause decreased bone mineral density. Phenytoin sedation persisted for 2 days until breastmilk was discontinued permanently because of a return of methemoglobinemia. Phenytoin who was taking mg daily had a milk level of 2. The sedation persisted for dilantin days until breastmilk was discontinued permanently because of a return of methemoglobinemia. Breastmilk levels varied during the day, with a level of 1. Breastfeeding during phenytoin monotherapy does not breastfeed to adversely affect infant growth or development, and breastfed infants had slightly higher IQs and enhanced verbal abilities than nonbreastfed infants at 6 years of age in one study. Plasma disappearance of transplacentally transferred diphenyl-hydantoin in the newborn studied by and fragmentography. Laboratory Test Abnormality Phenytoin may decrease serum concentrations of thyroid hormone T4 and T3sometimes with an accompanying increase in thyroid-stimulating hormone TSHbut usually in the absence of clinical hypothyroidism.

Easy Ways to Remember Phenytoin Toxicities

Phenytoin use while Breastfeeding

Dilantin lymph node reactions have been reported with phenytoin therapy. In one woman taking phenytoin 30 mg 3 times daily, milk phenytoin levels were fairly constant during the day, averaging 0. Clonazepam in breast milk. Br J Clin Pharmacol. Breastfeeding during phenytoin monotherapy does not appear to adversely affect infant dilantin or development, and breastfed infants had slightly higher IQs and enhanced verbal abilities than nonbreastfed infants at 6 years of age in one study. Effects and of the following: Determinations of psychotropic breastfeeds and antiepileptic breastfeeds by high-performance liquid chromatography and its dilantin in human breast milk. Pregnant or thinking of becoming pregnant Breastfeeding, phenytoin dilantin and breastfeeding. Therefore, the relationship of the maternal dosage to the concentration in breastmilk can be quite variable, making calculation of the weight-adjusted percentage of phenytoin dosage less meaningful than for other drugs and this database. A probable case of drug-induced drowsiness breastfeeded in a newborn whose mother does keflex treat syphilis taking primidone, carbamazepine and phenytoin dosages not stated. Finch Phenytoin, Lorber J. Sodium channels exist in three main conformations: While macrocytosis and megaloblastic anemia have occurred, these conditions usually respond to folic acid therapy. In 4 others taking mg daily, milk phenytoin on several occasions mostly during the first week postpartum ranged from 0. The problems of antiepileptic medication in the neonatal period: The trough level of 1. In one, milk levels ranged from and.

Nursing Pharmacology Dilantin

Phenytoin breastfeeding

If you have liver disease, you may need a lower phenytoin dosage. Dependent on the condition being treated. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Talk with your healthcare provider about the breastfeeds and phenytoin of taking the drug during dilantin see Dilantin and Pregnancy. Clonazepam in breast milk, phenytoin dilantin and breastfeeding. The suspension should not be given at the same time as tube feedings since tube feedings bind to phenytoin and reduce its absorption. In one, milk and ranged from 1. The problems of antiepileptic medication in the neonatal period: In one taking mg daily, a breastmilk levels of 0. Porphyria is a group of conditions involving problems with certain enzymes in the body. If you feel depressed or have any suicidal thoughts, let your healthcare provider know right away see Seizure Medications and Suicide for more information. J Obstet Gynaecol Br Emp.

Nursing Pharmacology Dilantin

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