Codeine allergic reactions

They can appear anywhere on the body, including the face, lips, tongue , throat, or ears. Hives vary in size from a pencil eraser to a dinner plate , and may join together to form larger areas known as plaques. They can last for hours, or up to one day before fading. Angioedema is similar to hives, but the swelling occurs beneath the skin instead of on the surface.

Angioedema is characterized by deep swelling around the eyes and lips and sometimes of the genitals, hands, and feet. It generally lasts longer than hives, but the swelling usually goes away in less than 24 hours. Rarely, angioedema of the throat, tongue , or lungs can block the airways, causing difficulty breathing. This may become life threatening. What Causes Hives and Angioedema? Allergic hives and angioedema form when, in response to histamine , blood plasma leaks out of small blood vessels in the skin.

Acetaminophen In acetaminophen overdosage, dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma and thrombocytopenia may also occur. Early symptoms following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion.

In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams or fatalities with less than 15 grams. Treatment A single or multiple overdose with acetaminophen and codeine is a potentially lethal polydrug overdose and consultation with a regional poison control center is recommended.

Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced mechanically, or with syrup of ipecac , if the patient is alert adequate pharyngeal and laryngeal reflexes. The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids. Vasopressors and other supportive measures should be employed as indicated.

A cuffed endo-tracheal tube should be inserted before gastric lavage of the unconscious patient and, when necessary, to provide assisted respiration. Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysis , or preferably hemodialysis , may be considered.

If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Naloxone , a narcotic antagonist , can reverse respiratory depression and coma associated with opioid overdose.

Since the duration of action of codeine may exceed that of the naloxone, the patient should be kept under continuous surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.

A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Many confuse intolerance with severe allergic reactions anaphylaxis warranting discontinued use of opioids in the same class. As an atypical opioid, this unique analgesic is one alternative for TRUE allergies.

There are individual and ethnic variables that makes some slow or ultra-rapid metabolizers. Furthermore, certain medications heart, antidepressants, etc can affect these drugs. This can cause life-threatening withdrawal symptoms in the baby after it is born.

Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant. Do not breast-feed while taking codeine. This medicine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby. How should I take codeine? Take codeine exactly as prescribed by your doctor. Follow all directions on your prescription label.

Codeine can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.

Gastric lavage should be carried out and a saline purgative may then be given to reduce absorption from gastro — intestinal tract. Symptomatic treatment of respiratory embarrassment should be given. If respiration is seriously depressed intravenous naloxone HCl may be required.

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